| TIGERS | 28-4 | COWBOYS |
| HULL FC | 24-26 | WIGAN |
| PHILADELPHIA | 10-2 | S. FRANCISCO |
| OAKLAND | 5-3 | MILWAUKEE |
| BOSTON | 4-9 | TAMPA BAY |
| ST LOUIS | 8-0 | CGO. CUBS |
| LA DODGERS | 8-2 | SAN DIEGO |
| MIAMI | 5-4 | MINNESOTA |
| CGO. SOX | 0-4 | NY METS |
| BALTIMORE | 2-11 | TORONTO |
| CLEVELAND | 1-7 | HOUSTON |
| ATLANTA | 4-1 | CINCINNATI |
| COMUNICACION. | 2-1 | MARATHON |
| ALIANZA FC | 5-1 | SAN FRANCISCO |
| FORGE FC | 2-1 | ANTIGUA GFC |
| LIBERTAD | 0-3 | GREMIO |
| Aggregate 0-5 | ||
| UNI. CATOLICA | 3-2 | INDEPENDIENTE |
| Aggregate 3-3- INDEPENDIENTE on away goals | ||
| WANDERERS | 1-2 | CORINTHIANS |
| Aggregate 1-4 | ||
| JABLONEC | 0-0 | PYUNIK |
| Aggregate 1-2 | ||
| FRANKFURT | 2-1 | FC FLORA |
| Aggregate 4-2 | ||
| BRONDBY | 4-1 | LECHIA GDANSK |
| after extra time - Aggregate 5-3 | ||
| APOLLON | 3-1 | SHAMROCK |
| after extra time - Aggregate 4-3 | ||
| DEBRECEN | 1-4 | TORINO |
| Aggregate 1-7 | ||
| LUGANSK | 1-0 | PODGORICA |
| Aggregate 4-1 | ||
| M. HAIFA | 2-1 | STRASBOURG |
| Aggregate 3-4 | ||
| CRUSADERS | 1-4 | WOLVES |
| Aggregate 1-6 | ||
| STURM | 2-1 | HAUGESUND |
| Aggregate 2-3 | ||
| VADUZ | 2-0 | VIDEOTON |
| after extra time - Aggregate 2-1 | ||
| LEVSKI | 0-4 | LARNACA |
| Aggregate 0-7 | ||
| KUPS KUOPIO | 0-0 | LEGIA |
| Aggregate 0-1 | ||
| CONSTANTA | 2-1 | GAND |
| Aggregate 5-7 | ||
| LIMASSOL | 0-1 | ARIS |
| Aggregate 0-1 | ||
| OSIJEK | 1-0 | CSKA SOFIA |
| Aggregate 1-1- CSKA SOFIA 4-3 on pen. | ||
| PARTIZAN | 3-0 | GAP CONNAH |
| Aggregate 4-0 | ||
| NEFTCI | 3-0 | ARS. TULA |
| Aggregate 4-0 | ||
| RIGA FC | 2-1 | PIAST |
| Aggregate 4-4- RIGA FC on away goals | ||
| STEAUA | 2-3 | ALASHKERT |
| Aggregate 5-3 | ||
| ATROMITOS | 3-2 | FC DAC 1904 |
| Aggregate 5-3 | ||
| LUDOGORETS | 4-0 | VALUR |
| Aggregate 5-1 | ||
| HACKEN | 0-3 | AZ ALKMAAR |
| Aggregate 0-3 | ||
| SPAR. TRNAVA | 3-1 | LOK. PLOVDIV |
| Aggregate 3-3- LOK. PLOVDIV on away goals | ||
| NIEDERKORN | 0-0 | RANGERS |
| Aggregate 0-2 | ||
| GZIRA UTD | 2-2 | VENTSPILS |
| Aggregate 2-6 | ||
| ORDABASY | 2-3 | BOLESLAV |
| Aggregate 3-4 | ||
| LIEPAJAS | 0-1 | NORRKOPING |
| Aggregate 0-3 | ||
| SHERIFF | 1-1 | FK PARTIZANI |
| Aggregate 2-1 | ||
| ASTANA 64 | 4-1 | UE ST COLOMA |
| Aggregate 4-1 | ||
| LINFIELD | 1-0 | HB TORSHAVN |
| Aggregate 3-2 | ||
| ABERDEEN | 5-0 | CHIKHURA |
| Aggregate 6-1 | ||
| ESBJERG | 0-0 | SOLIGORSK |
| Aggregate 0-2 | ||
| FCK ALMATY | 1-1 | H. BEER SHEVA |
| Aggregate 1-3 | ||
| TBILISI | 3-0 | QABALA |
| Aggregate 5-0 | ||
| UNI. CRAIOVA | 0-0 | HONVED |
| Aggregate 0-0- UNI. CRAIOVA 3-1 on pen. | ||
| MALMO | 3-2 | DOMZALE |
| Aggregate 5-4 | ||
| STJARNAN | 1-3 | ESPANYOL |
| Aggregate 1-7 | ||
| ZRINJSKI | 2-1 | UTRECHT |
| after extra time - Aggregate 3-2 | ||
| LJUBLJANA | 0-1 | MALATYASPOR |
| Aggregate 2-3 | ||
| KI KLAKSVIK | 0-1 | LUZERN |
| Aggregate 0-2 | ||
| VITORIA | 4-0 | JEUN. ESCH |
| Aggregate 5-0 | ||
| ESWATINI | 1-3 | MOZAMBIQUE |
| ZAMBIA | 15-0 | MAURITIUS |
| NAMIBIA | 0-1 | BOTSWANA |
| INDIANA | 61-59 | ATLANTA |
| WASHINGTON |
| Final |
| KYRGIOS def. MEDVEDEV |
| CABO SAN LUCAS |
| Final |
| SCHWARTZMAN def. FRITZ |
| KITZBUHEL |
| Final |
| THIEM def. RAMOS-VINOL |
| SAN JOSE |
| Final |
| ZHENG def. SABALENKA |
| WASHINGTON |
| Final |
| PEGULA def. GIORGI |
| KARLSRUHE |
| Final |
| TIG def. VAN UYTVANC |